Located in what is known as the Pee Dee Region of South Carolina, Williamsburg County is situated midway between Interstate 95 (28 miles), Interstate 26 (55 miles), and Interstate 20 (49 miles).  The County seat of Kingstree is less than an hour's drive from Charleston and the Myrtle Beach Grand Strand area - one of the nation's leading vacation destinations.

Major highways traversing Williamsburg County include U.S. 521, U.S. 52, and South Carolina highways 377, 527, and 261. The County is less than an hour's drive to the Port of Charleston, and has access to rail lines that serve the entire Eastern U.S.

Williamsburg County is within a single day's drive to all of the major metropolitan areas in the Eastern U.S. including New York City, Miami, Philadelphia, Washington, DC, Charlotte, Atlanta, Tampa, Birmingham, Nashville, Cincinnati, Cleveland, and Detroit.